K

Peptide Research

GLP3-RT

SKU: RT10

Retatrutide (LY3437943) is a triple agonist targeting GLP-1, GIP, and glucagon receptors. GLP-1 activation enhances glucose-dependent insulin secretion and satiety; GIP agonism amplifies incretin response and modulates adipose tissue; glucagon receptor activation increases energy…

View Catalog →For Research Use Only
GLP3-RT

Mechanism of Action

Retatrutide (LY3437943) is a triple agonist targeting GLP-1, GIP, and glucagon receptors. GLP-1 activation enhances glucose-dependent insulin secretion and satiety; GIP agonism amplifies incretin response and modulates adipose tissue; glucagon receptor activation increases energy expenditure and hepatic lipid oxidation. Phase 2 trials showed up to 24.2% weight reduction at 48 weeks.

Research Studies

1 peer-reviewed study curated for GLP3-RT.

Other — 1

Related Research

Represents next-generation incretin research beyond GLP2-TZ (dual agonist) and Tesamorelin (GHRH-focused metabolic). Researchers comparing metabolic peptide classes often evaluate these side-by-side. Complementary to MOTS-c for exercise-mimetic pathway studies.