PMID: 25738459
Peptide Research
MOTS-c
SKU: MS10
MOTS-c (Mitochondrial ORF of the 12S rRNA-c) is a 16-amino-acid peptide encoded within mitochondrial DNA. Under metabolic stress, it translocates to the nucleus in an AMPK-dependent manner and regulates stress-adaptation gene expression. It acts primarily through the Folate-AICAR…
View Catalog →For Research Use Only
Mechanism of Action
MOTS-c (Mitochondrial ORF of the 12S rRNA-c) is a 16-amino-acid peptide encoded within mitochondrial DNA. Under metabolic stress, it translocates to the nucleus in an AMPK-dependent manner and regulates stress-adaptation gene expression. It acts primarily through the Folate-AICAR-AMPK pathway, influencing glucose metabolism, GLUT4 translocation, and fatty acid oxidation.
Research Studies
4 peer-reviewed studies curated for MOTS-c.
Other — 4
PMID: 29983246
Kim SJ et al. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018
View on PubMed →PMID: 33639272
Yu WD et al. The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro. Mitochondrion. 2021
View on PubMed →PMID: 36233287
Merry TL et al. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. 2022
View on PubMed →Related Research
Complementary to SS-31 (mitochondrial membrane stabilization) and NAD+ (sirtuin/AMPK co-regulation). Researchers studying exercise mimetics often evaluate MOTS-c alongside metabolic peptides and GLP-1 agonists for comprehensive metabolic health protocols.