PMID: 14969422
Peptide Research
Selank
SKU: SK10
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin, with an added Pro-Gly-Pro C-terminal for metabolic stability. Clinical studies in Russia show anxiolytic activity comparable to benzodiazepines without sedation, toler…
View Catalog →For Research Use Only
Mechanism of Action
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin, with an added Pro-Gly-Pro C-terminal for metabolic stability. Clinical studies in Russia show anxiolytic activity comparable to benzodiazepines without sedation, tolerance, or withdrawal. Research indicates modulation of GABAergic and serotonergic systems, influence on enkephalin metabolism, and rapid elevation of BDNF in the rat hippocampus.
Research Studies
3 peer-reviewed studies curated for Selank.
Other — 3
PMID: 26973530
Volkova A et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016
View on PubMed →PMID: 18454096
Zozulya AA et al. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. 2008
View on PubMed →Related Research
CNS-focused peptide often paired with Semax for complementary cognitive and stress-response research (developed by the same Russian Academy of Sciences group). Researchers investigating sleep and HPA axis modulation study it alongside PT-141 and Kisspeptin for broader neuroendocrine context.