PMID: 32554501
Peptide Research
SS31
SKU: 2S10
SS-31 (D-Arg-Dmt-Lys-Phe-NH2) is a mitochondria-targeted tetrapeptide that selectively binds cardiolipin on the inner mitochondrial membrane via electrostatic interactions. It stabilizes cristae architecture, reduces cardiolipin peroxidation, and preserves electron transport chai…
View Catalog →For Research Use Only
Mechanism of Action
SS-31 (D-Arg-Dmt-Lys-Phe-NH2) is a mitochondria-targeted tetrapeptide that selectively binds cardiolipin on the inner mitochondrial membrane via electrostatic interactions. It stabilizes cristae architecture, reduces cardiolipin peroxidation, and preserves electron transport chain function. Unlike conventional antioxidants, it concentrates in mitochondria independent of membrane potential.
Research Studies
3 peer-reviewed studies curated for SS31.
Other — 3
PMID: 23846690
Birk AV et al. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol. 2013
View on PubMed →PMID: 32273339
Mitchell W et al. The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics. 2020
View on PubMed →Related Research
Frequently studied alongside MOTS-c (complementary mitochondrial signaling), NAD+ (mitochondrial redox cofactor), and Glutathione (cellular antioxidant defense). Researchers investigating age-related mitochondrial dysfunction often pair SS-31 with Epithalon for combined mitochondrial and telomere-focused protocols.